My issue was a combination of three things:
1. Andromeda being in just the right position when overhead to have my camera in-line with the pier
2. My OAG and guide camera reducing the clearance between my scope and the pier
3. The location I chose to mount my USB hub was less than optimal
Interestingly enough, with all of the imaging I’ve done, I have just never run into this issue...just the luck of the draw with the target I chose this time. Anyways, moving the USB hub helped to clear things up.